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Title:
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Ultrasound imaging of the salivary glands in patients with primary Sjögren’s syndrome and in volunteers without xerostomia
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Author:
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Rao, Sunitha; Walia, Damandeep |
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Abstract:
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Sjögren’s Syndrome (SS) is an autoimmune disorder involving the salivary glands and lacrimal glands. Salivary glandinvolvement may be detected by noninvasive imaging studies such as Ultrasound. Ultrasound is less expensive and moreavailable than other forms of imaging. The purpose of this pilot study is to assess the utility of high resolution ultrasound inthe non-invasive diagnosis of SS.
We enrolled 20 subjects in this study. 10 had SS (9 female and 1 male) and 10 were control subjects (10 female). Theclinical diagnosis of SS was previously established by the presence of auto antibodies such as anti-SS-A (Ro), anti-SS-B (La)or minor salivary gland biopsy. The mean ages for the control group (55.6 + 14.5) and patients with SS (53.9 + 17.5) weresimilar. After obtaining informed consent, high resolution ultrasound images of the parotid and submandibular glands wereobtained. Two physicians, blinded to the subjects’ identity and clinical history, interpreted the images. The images were graded on a 4point scale: 1 definitely normal, 2 probably normal, 3 probably abnormal or 4 definitely abnormal. 9 out of 10 controlsubjects were rated as normal by interpreter 1 (mean score of 1.6). 5 out 10 control subjects were rated as normal byinterpreter 2 (mean score of 2.5). 9 out of 10 subjects with SS were rated as abnormal by both interpreters (mean scores of3.5 and 3.6). The findings in this small series suggest that ultrasound is sensitive for the non-invasive diagnosis of SS. |
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Description:
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Clinical Studies I
Room G026 Dykes
8:32 AM
Abstract 124 |
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URI:
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http://hdl.handle.net/2271/74
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Date:
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2006-05-19 |
