The role of estrogen in trigeminal hypersensitivity

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Show simple item record Liverman, Christopher 2006-06-30T16:24:14Z 2006-06-30T16:24:14Z 2006-06-30T16:24:14Z
dc.description Neuroscience III Room 1028 Dykes 2:06 PM Abstract 209 en
dc.description.abstract Migraine and temporomandibular disease are three times more common in women than in men and temporally related to the hormonal fluctuations of the menstrual cycle. We examined mechanical sensitivity of the temporomandibular joint in ovariectomized rats in a 2x2 model of TMJ inflammation and estrogen replacement. Mechanical sensitivity of the TMJ was increased by administration of Complete Freund’s Adjuvant (CFA) and estrogen, with a synergistic effect achieved from concurrent administration of CFA and estrogen. Because the MAP kinase Extracellular-signal regulated kinase (ERK) has been implicated in hypersensitivity of neurons following inflammation, ERK activation was examined in trigeminal ganglia of rats from the 2x2 model using immunohistochemistry. The number of cells expressing activated ERK in each group paralleled the mechanical sensitivity data. Because estrogen has been shown to activate ERK, we examined the distribution of Estrogen Receptor α and the rapid signaling estrogen receptor GPR30 in trigeminal ganglia from the same animals. Both receptors were widely distributed in trigeminal neurons, and ERα was downregulated by estrogen replacement. en
dc.description.sponsorship Berman, Nancy Anatomy and Cell Biology en
dc.format.extent 40023040 bytes
dc.format.mimetype application/
dc.language.iso en_US en
dc.subject Estrogen en
dc.subject Trigeminal ganglion en
dc.subject Migraine en
dc.subject ERK en
dc.title The role of estrogen in trigeminal hypersensitivity en
dc.type Presentation en

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