Whole brain and cortical volume measurement in early alzheimer disease

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dc.contributor.author Thomas, George
dc.date.accessioned 2006-06-30T20:09:36Z
dc.date.available 2006-06-30T20:09:36Z
dc.date.issued 2006-06-30T20:09:36Z
dc.identifier.uri http://hdl.handle.net/2271/152
dc.description Neuroscience II Room 1028 Dykes 10:24 AM Abstract 162 en
dc.description.abstract Introduction: Alzheimer disease (AD) is a neurodegenerative disorder characterized by progressive memory loss and dementia. Associated structural brain changes include generalized cortical atrophy, widening of surface sulci and loss of entorhinal cortex and hippocampus volume. We sought to develop quantitative techniques of assessing whole brain and cortical atrophy early in the course of AD that would be both efficient and minimize observer subjectivity. Methods: Sixty-two research subjects were evaluated clinically by both a trained psychometrician and a neurologist into one of two groups based on the results of the clinical evaluation; nondemented (CDR 0) and early-stage AD (CDR 0.5 &1). MRI brain scans were analyzed using the Statistical Parametric Mapping (SPM) software package. Prior to processing, the MRI scan data were converted from DICOM into the SPM99/Analyze format. Next a study-specific template and apriori images were created. The MPRAGE sequences (T1-weighted) were subsequently processed in three steps: affine normalization, three-class tissue segmentation and brain extraction. The final results were reported by SPM as a voxel count of each tissue class (gray matter, white mater, and cerebrospinal fluid). Normalized gray, white, and cerebrospinal fluid volumes were reported as a percentage of the total intracranial volume. Results: Whole brain volume was larger (74.19%) in the nondemented than in the early-stage AD group (71.82%, p<0.001). The mean gray matter volume of the nondemented group was 46.71%, while that of the demented group was 44.79%. Statistical analysis again showed significant differences across groups (p<0.001). As expected there was a corresponding increased volume of cerebrospinal fluid in the demented group (nondemented 28.35% vs. demented 28.18%, p < 0.001). There was no difference in the white matter volume between groups (nondemented 27.48% vs. demented 27.03%, p = 0.33). Conclusions: This technique appears to be a sensitive method of detecting early whole brain and gray matter volume loss associated with early dementia. Additional advantages of this highly automated technique are the ability to quantitatively describe changes in brain volume, and the lack of operator interventions that may introduce error by interpretation. en
dc.description.sponsorship Burns, Jeff Neurology en
dc.format.extent 1717248 bytes
dc.format.mimetype application/vnd.ms-powerpoint
dc.language.iso en_US en
dc.subject Alzheimer disease en
dc.subject MRI en
dc.subject brain en
dc.title Whole brain and cortical volume measurement in early alzheimer disease en
dc.type Presentation en

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