Browsing KU Med Libraries by Submit Date

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Browsing KU Med Libraries by Submit Date

Now showing items 41-60 of 63

A Markov blanket-based method for detecting causal SNPs in GWAS

Unknown author (2010-04-29)

Abstract Background Detecting epistatic interactions associated with complex and common diseases can help to improve prevention, diagnosis and treatment of these diseases. With the development of genome-wide association ...
Application of Kernel Functions for Accurate Similarity Search in Large Chemical Databases

Unknown author (2010-04-29)

Abstract Background Similaritysearch in chemical structure databases is an important problem with many applications in chemical genomics, drug design, and efficient chemical probe screening among others. It is widely ...
Comparison of a reduced carbohydrate and reduced fat diet for LDL, HDL, and VLDL subclasses during 9-months of weight maintenance subsequent to weight loss

LeCheminant, James D; Smith, Bryan K; Westman, Eric C; Vernon, Mary C; Donnelly, Joseph E (2010-06-01)

Abstract Objectives This study compared LDL, HDL, and VLDL subclasses in overweight or obese adults consuming either a reduced carbohydrate (RC) or reduced fat (RF) weight maintenance diet for 9 months following significant ...
The dietary bioflavonoid quercetin synergizes with epigallocathechin gallate (EGCG) to inhibit prostate cancer stem cell characteristics, invasion, migration and epithelial-mesenchymal transition.

Tang, Su-Ni; Singh, Chandan; Nall, Dara; Meagher, Daniel; Shankar, Sharmila; Srivastava, Rakesh K (2010-08-18)

Abstract Background Much attention has been recently focused on the role of cancer stem cells (CSCs) in the initiation and progression of solid malignancies. Since CSCs are able to proliferate and self-renew extensively ...
Transcriptomic responses in mouse brain exposed to chronic excess of the neurotransmitter glutamate

Wang, Xinkun; Bao, Xiaodong; Pal, Ranu; Agbas, Abdulbaki; Michaelis, Elias K (2010-06-07)

Abstract Background Increases during aging in extracellular levels of glutamate (Glu), the major excitatory neurotransmitter in the brain, may be linked to chronic neurodegenerative diseases. Little is known about the ...
Phosphatidylinositol 3 kinase modulation of trophoblast cell differentiation

Kent, Lindsey N.; Konno, Toshihiro; Soares, Michael J. (2010-09-14)

Abstract Background The trophoblast lineage arises as the first differentiation event during embryogenesis. Trophoblast giant cells are one of several end-stage products of trophoblast cell differentiation in rodents. These ...
Lubiprostone ameliorates the cystic fibrosis mouse intestinal phenotype

De Lisle, Robert C; Mueller, Racquel; Roach, Eileen (2010-09-15)

Abstract Background Cystic fibrosis (CF) is caused by mutations in the CFTR gene that impair the function of CFTR, a cAMP-regulated anion channel. In the small intestine loss of CFTR function creates a dehydrated, acidic ...
The effect of starting point placement technique on thoracic transverse process strength: an ex vivo biomechanical study

Brown, Barrett S; McIff, Terence E; Glattes, Rudolph C; Burton, Douglas C; Asher, Marc A (2010-07-13)

Abstract Background The use of thoracic pedicle screws in spinal deformity, trauma, and tumor reconstruction is becoming more common. Unsuccessful screw placement may require salvage techniques utilizing transverse process ...
Immortalized, pre-malignant epithelial cell populations contain long-lived, label-retaining cells that asymmetrically divide and retain their template DNA

Bussard, Karen M; Boulanger, Corinne A; Kittrell, Frances S; Behbod, Fariba; Medina, Daniel; Smith, Gilbert H (2010-10-21)

Abstract Introduction During selective segregation of DNA, a cell asymmetrically divides and retains its template DNA. Asymmetric division yields daughter cells whose genome reflects that of the parents, simultaneously ...
Tobacco use amongst out of school youth in a Local Government Area in Nigeria.

Adebiyi, Akindele O; Faseru, Babalola; Sangowawa, Adesola O; Owoaje, Eme T (2010-10-18)

Abstract Introduction Out-of-school adolescents are often neglected when planning for tobacco prevention programmes whereas they are more vulnerable. Few studies exist in Nigeria about their pattern of tobacco use to serve ...
Development and validation of a FACS-based lipoprotein localization screen in the Lyme disease spirochete Borrelia burgdorferi

Kumru, Ozan S; Schulze, Ryan J; Slusser, Joyce G; Zuckert, Wolfram R (2010-11-03)

Abstract Background In our previous studies on lipoprotein secretion in the Lyme disease spirochete Borrelia burgdorferi, we used monomeric red fluorescent protein 1 (mRFP1) fused to specifically mutated outer surface ...
Mammalian oocytes are targets for prostaglandin E2 (PGE2) action

Duffy, Diane M; McGinnis, Lynda K; VandeVoort, Catherine A; Christenson, Lane K (2010-11-01)

Abstract Background The ovulatory gonadotropin surge increases synthesis of prostaglandin E2 (PGE2) by the periovulatory follicle. PGE2 actions on granulosa cells are essential for successful ovulation. The aim of the ...
Sex partnerships, health, and social risks of young men leaving jail: analyzing data from a randomized controlled trial

Ramaswamy, Megha; Freudenberg, Nicholas (2010-11-10)

Abstract Background Young men involved in the criminal justice system face disproportionately high rates of sexual risk behavior, drug, use, and violence. Little is known about how their involvement in sex partnerships ...
Expression of hepatocytic- and biliary-specific transcription factors in regenerating bile ducts during hepatocyte-to-biliary epithelial cell transdifferentiation

Limaye, Pallavi B; Bowen, William C; Orr, Anne; Apte, Udayan M; Michalopoulos, George K (2010-12-02)

Abstract Background Under compromised biliary regeneration, transdifferentiation of hepatocytes into biliary epithelial cells (BEC) has been previously observed in rats, upon exposure to BEC-specific toxicant methylene ...
HTLV-I p30 inhibits multiple S phase entry checkpoints, decreases cyclin E-CDK2 interactions and delays cell cycle progression.

Baydoun, Hicham H; Pancewicz, Joanna; Bai, XueTao; Nicot, Christophe (2010-11-23)

Abstract Background Human T-cell leukemia virus type I (HTLV-I) has efficiently adapted to its host and establishes a persistent infection characterized by low levels of viral gene expression and slow proliferation of ...
ACCISS study rationale and design: activating collaborative cancer information service support for cervical cancer screening

Cofta-Woerpel, Ludmila; Randhawa, Veenu; McFadden, H. GENE; Fought, Angela; Bullard, Emily; Spring, Bonnie (2009-12-02)

Abstract Background High-quality cancer information resources are available but underutilized by the public. Despite greater awareness of the National Cancer Institute's Cancer Information Service among low-income African ...
Resistance exercise training lowers HbA1c more than aerobic training in adults with type 2 diabetes

Bweir, Salameh; Al-Jarrah, Muhammed; Almalty, Abdul-Majeed; Maayah, Mikhled; Smirnova, Irina V.; Novikova, Lesya; Stehno-Bittel, Lisa (2009-12-10)

Abstract Background The aim of this study was to compare the effects of 10 weeks of resistance or treadmill exercises on glycemic indices levels prior to and immediately following exercise in adults with type 2 diabetes. ...
A longitudinal study of tobacco use among American Indian and Alaska Native tribal college students

Faseru, Babalola; Daley, Christine M; Gajewski, Byron; Pacheco, Christina M; Choi, Won S (2010-10-18)

Abstract Background American Indians (AI) have the highest smoking rates of any ethnic group in the US (40.8%), followed most closely by African Americans (24.3%) and European Americans (23.6%). AI smokers also have more ...
An in vitro study comparing a peripherally inserted central catheter to a conventional central venous catheter: no difference in static and dynamic pressure transmission

Latham, Heath E; Dwyer, Timothy T; Gregg, Bethene L; Simpson, Steven Q (2010-10-12)

Abstract Background Early goal directed therapy improves survival in patients with septic shock. Central venous pressure (CVP) monitoring is essential to guide adequate resuscitation. Use of peripherally inserted central ...
Lipid droplets as ubiquitous fat storage organelles in C. elegans

Zhang, Shaobing O; Trimble, Rhonda; Guo, Fengli; Mak, Ho Yi (2010-12-08)

Abstract Background Lipid droplets are a class of eukaryotic cell organelles for storage of neutral fat such as triacylglycerol (TAG) and cholesterol ester (CE). We and others have recently reported that lysosome-related ...