Browsing School of Medicine by Author "Yu-Jui Wan"

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Fenretinide-induced apoptosis of Huh-7 hepatocellular carcinoma is retinoic acid receptor ß dependent

Pengli Bu; Yu-Jui Wan (BioMedCentral, 2009-03-17)

BACKGROUND:Retinoids are used to treat several types of cancer; however, their effects on liver cancer have not been fully characterized. To investigate the therapeutic potential of retinoids on hepatocellular carcinoma ...
Hepatocyte RXRalpha deficiency in matured and aged mice: impact on the expression of cancer-related hepatic genes in a gender-specific manner

Minglei Guo; Lei Gong; Lin He; Lois Lehman-McKeeman; Yu-Jui Wan (BioMedCentral, 2008-05-01)

BACKGROUND:The occurrence of liver cancer is higher in males than in females, and the incidence increases during aging. Signaling pathways regulated by retinoid × receptor a (RXRa) are involved in hepatocellular carcinogenesis. ...
Linkage disequilibrium blocks, haplotype structure, and htSNPs of human CYP7A1 gene

Kaori Nakamoto; Shuang Wang; Robert Jenison; Grace Guo; Curtis Klaassen; Yu-Jui Wan; Xiao-bo Zhong (BioMedCentral, 2005-05-27)

BACKGROUND:Cholesterol 7-alpha-hydroxylase (CYP7A1) is the rate limiting enzyme for converting cholesterol into bile acids. Genetic variations in the CYP7A1 gene have been associated with metabolic disorders of cholesterol ...