The role of HLA-G in human pregnancy

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dc.contributor.author Joan Hunt en_US
dc.contributor.author Daudi Langat en_US
dc.contributor.author Ramsey McIntire en_US
dc.contributor.author Pedro Morales en_US
dc.date.accessioned 2009-05-05T16:14:51Z
dc.date.available 2006 - en_US
dc.date.available 2009-05-05T16:14:51Z
dc.date.issued 2006-02-06 en_US
dc.identifier.citation Joan Hunt;Daudi Langat;Ramsey McIntire;Pedro Morales: The role of HLA-G in human pregnancy. Reproductive Biology and Endocrinology 2006, 4(Suppl 1):S10. en_US
dc.identifier.uri 0 en_US
dc.identifier.uri http://hdl.handle.net/2271/602
dc.description.abstract Pregnancy in mammals featuring hemochorial placentation introduces a major conflict with the mother's immune system, which is dedicated to repelling invaders bearing foreign DNA and RNA. Numerous and highly sophisticated strategies for preventing mothers from rejecting their genetically different fetus(es) have now been identified. These involve production of novel soluble and membrane-bound molecules by uterine and placental cells. In humans, the placenta-derived molecules include glycoproteins derived from the HLA class Ib gene, HLA-G. Isoforms of HLA-G saturate the maternal-fetal interface and circulate in mothers throughout pregnancy. Uteroplacental immune privilege for the fetus and its associated tissues is believed to result when immune cells encounter HLA-G. Unequivocally demonstration of this concept requires experiments in animal models. Both the monkey and the baboon express molecules that are similar but not identical to HLA-G, and may comprise suitable animal models for establishing a central role for these proteins in pregnancy. en_US
dc.format.extent 339453 bytes
dc.format.extent 2910 bytes
dc.format.extent 12055 bytes
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dc.format.extent 43 bytes
dc.format.mimetype application/pdf
dc.format.mimetype text/plain
dc.format.mimetype application/octet-stream
dc.format.mimetype application/octet-stream
dc.format.mimetype application/octet-stream
dc.language en en_US
dc.language.iso en_US
dc.publisher BioMedCentral en_US
dc.relation.ispartof 1477-7827 en_US
dc.relation.hasversion http://www.biomedcentral.com/content/pdf/1477-7827-4-S1-S10.pdf en_US
dc.rights This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. en_US
dc.rights.uri http://creativecommons.org/licenses/by/2.0 en_US
dc.subject.mesh Alkaline Phosphatase/metabolism en_US
dc.subject.mesh Animals en_US
dc.subject.mesh Cell Nucleus/chemistry en_US
dc.subject.mesh Cells, Cultured en_US
dc.subject.mesh DNA-Binding Proteins/analysis/ genetics en_US
dc.subject.mesh Female en_US
dc.subject.mesh Fibroblasts/chemistry en_US
dc.subject.mesh Flow Cytometry en_US
dc.subject.mesh Fluorescent Dyes en_US
dc.subject.mesh HMGB Proteins/analysis/ genetics en_US
dc.subject.mesh Homeodomain Proteins/analysis/ genetics en_US
dc.subject.mesh Immunohistochemistry en_US
dc.subject.mesh Male en_US
dc.subject.mesh Octamer Transcription Factor-3/analysis/ genetics en_US
dc.subject.mesh RNA, Messenger/analysis en_US
dc.subject.mesh Reverse Transcriptase Polymerase Chain Reaction en_US
dc.subject.mesh SOXB1 Transcription Factors en_US
dc.subject.mesh Stem Cells/chemistry/enzymology en_US
dc.subject.mesh Swine en_US
dc.subject.mesh Transcription Factors/analysis/ genetics en_US
dc.subject.mesh Umbilical Cord/ chemistry/cytology en_US
dc.title The role of HLA-G in human pregnancy en_US
dc.type article en_US
dc.date.captured 2009-04-27 en_US
dc.identifier.doi doi:10.1186/1477-7827-4-S1-S10 en_US
dc.identifier.pmid 16460563 en_US

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This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Except where otherwise noted, this item's license is described as This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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