Resting myocardial perfusion quantification with CMR arterial spin labeling at 1.5 T and 3.0 T

Archie Digital Collections

Show simple item record

dc.contributor.author Benjamin Northrup en_US
dc.contributor.author Kyle McCommis en_US
dc.contributor.author Haosen Zhang en_US
dc.contributor.author Shuddhadeb Ray en_US
dc.contributor.author Pamela Woodard en_US
dc.contributor.author Robert Gropler en_US
dc.contributor.author Jie Zheng en_US
dc.date.accessioned 2009-05-05T16:15:14Z
dc.date.available 2008 - en_US
dc.date.available 2009-05-05T16:15:14Z
dc.date.issued 2008-07-07 en_US
dc.identifier.citation Benjamin Northrup;Kyle McCommis;Haosen Zhang;Shuddhadeb Ray;Pamela Woodard;Robert Gropler;Jie Zheng: Resting myocardial perfusion quantification with CMR arterial spin labeling at 1.5 T and 3.0 T. Journal of Cardiovascular Magnetic Resonance 2008, 10(1):53. en_US
dc.identifier.uri http://www.jcmr-online.com/content/10/1/53 en_US
dc.identifier.uri http://hdl.handle.net/2271/606
dc.description.abstract BACKGROUND:The magnetic resonance technique of arterial spin labeling (ASL) allows myocardial perfusion to be quantified without the use of a contrast agent. This study aimed to use a modified ASL technique and T1 regression algorithm, previously validated in canine models, to calculate myocardial blood flow (MBF) in normal human subjects and to compare the accuracy and repeatability of this calculation at 1.5 T and 3.0 T. A computer simulation was performed and compared with experimental findings.RESULTS:Eight subjects were imaged, with scans at 3.0 T showing significantly higher T1 values (P < 0.001) and signal-to-noise ratios (SNR) (P < 0.002) than scans at 1.5 T. The average MBF was found to be 0.990 ± 0.302 mL/g/min at 1.5 T and 1.058 ± 0.187 mL/g/min at 3.0 T. The repeatability at 3.0 T was improved 43% over that at 1.5 T, although no statistically significant difference was found between the two field strengths. In the simulation, the accuracy and the repeatability of the MBF calculations were 61% and 38% higher, respectively, at 3.0 T than at 1.5 T, but no statistically significant differences were observed. There were no significant differences between the myocardial perfusion data sets obtained from the two independent observers. Additionally, there was a trend toward less variation in the perfusion data from the two observers at 3.0 T as compared to 1.5 T.CONCLUSION:This suggests that this ASL technique can be used, preferably at 3.0 T, to quantify myocardial perfusion in humans and with further development could be useful in the clinical setting as an alternative method of perfusion analysis. en_US
dc.format.extent 745200 bytes
dc.format.extent 2910 bytes
dc.format.extent 12055 bytes
dc.format.extent 0 bytes
dc.format.extent 43 bytes
dc.format.mimetype application/pdf
dc.format.mimetype text/plain
dc.format.mimetype application/octet-stream
dc.format.mimetype application/octet-stream
dc.format.mimetype application/octet-stream
dc.language en en_US
dc.language.iso en_US
dc.publisher BioMedCentral en_US
dc.relation.ispartof 1532-429X en_US
dc.relation.hasversion http://www.biomedcentral.com/content/pdf/1532-429X-10-53.pdf en_US
dc.rights This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. en_US
dc.rights.uri http://creativecommons.org/licenses/by/2.0 en_US
dc.title Resting myocardial perfusion quantification with CMR arterial spin labeling at 1.5 T and 3.0 T en_US
dc.type article en_US
dc.date.captured 2009-04-27 en_US
dc.identifier.doi doi:10.1186/1532-429X-10-53 en_US
dc.identifier.pmid 18606013 en_US

Files in this item

The following license files are associated with this item:

This item appears in the following Collection(s)

Show simple item record

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Except where otherwise noted, this item's license is described as This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Search Archie


Advanced Search

Browse

My Account

Statistics