Evolutionary history of bacteriophages with double-stranded DNA genomes

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dc.contributor.author Galina Glazko en_US
dc.contributor.author Vladimir Makarenkov en_US
dc.contributor.author Jing Liu en_US
dc.contributor.author Arcady Mushegian en_US
dc.date.accessioned 2009-05-05T16:16:00Z
dc.date.available 2007 - en_US
dc.date.available 2009-05-05T16:16:00Z
dc.date.issued 2006-05-30 en_US
dc.identifier.citation Galina Glazko;Vladimir Makarenkov;Jing Liu;Arcady Mushegian: Evolutionary history of bacteriophages with double-stranded DNA genomes. Biology Direct 2007, 2(1):36. en_US
dc.identifier.uri http://www.biology-direct.com/content/2/1/36 en_US
dc.identifier.uri http://hdl.handle.net/2271/616
dc.description.abstract BACKGROUND:Reconstruction of evolutionary history of bacteriophages is a difficult problem because of fast sequence drift and lack of omnipresent genes in phage genomes. Moreover, losses and recombinational exchanges of genes are so pervasive in phages that the plausibility of phylogenetic inference in phage kingdom has been questioned.RESULTS:We compiled the profiles of presence and absence of 803 orthologous genes in 158 completely sequenced phages with double-stranded DNA genomes and used these gene content vectors to infer the evolutionary history of phages. There were 18 well-supported clades, mostly corresponding to accepted genera, but in some cases appearing to define new taxonomic groups. Conflicts between this phylogeny and trees constructed from sequence alignments of phage proteins were exploited to infer 294 specific acts of intergenome gene transfer.CONCLUSION:A notoriously reticulate evolutionary history of fast-evolving phages can be reconstructed in considerable detail by quantitative comparative genomics.OPEN PEER REVIEW:This article was reviewed by Eugene Koonin, Nicholas Galtier and Martijn Huynen. en_US
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dc.format.extent 43 bytes
dc.format.mimetype application/pdf
dc.format.mimetype text/plain
dc.format.mimetype application/octet-stream
dc.format.mimetype application/octet-stream
dc.format.mimetype application/octet-stream
dc.language en en_US
dc.language.iso en_US
dc.publisher BioMedCentral en_US
dc.relation.ispartof 1745-6150 en_US
dc.relation.hasversion http://www.biomedcentral.com/content/pdf/1745-6150-2-36.pdf en_US
dc.rights This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. en_US
dc.rights.uri http://creativecommons.org/licenses/by/2.0 en_US
dc.title Evolutionary history of bacteriophages with double-stranded DNA genomes en_US
dc.type article en_US
dc.date.captured 2009-04-27 en_US
dc.identifier.doi doi:10.1186/1745-6150-2-36 en_US
dc.identifier.pmid 16734895 en_US

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This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Except where otherwise noted, this item's license is described as This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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