Hepatocyte RXRalpha deficiency in matured and aged mice: impact on the expression of cancer-related hepatic genes in a gender-specific manner

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dc.contributor.author Minglei Guo en_US
dc.contributor.author Lei Gong en_US
dc.contributor.author Lin He en_US
dc.contributor.author Lois Lehman-McKeeman en_US
dc.contributor.author Yu-Jui Wan en_US
dc.date.accessioned 2009-05-05T16:16:15Z
dc.date.available 2008 - en_US
dc.date.available 2009-05-05T16:16:15Z
dc.date.issued 2008-05-01 en_US
dc.identifier.citation Minglei Guo;Lei Gong;Lin He;Lois Lehman-McKeeman;Yu-Jui Wan: Hepatocyte RXRalpha deficiency in matured and aged mice: impact on the expression of cancer-related hepatic genes in a gender-specific manner. BMC Genomics 2008, 9(1):403. en_US
dc.identifier.uri http://www.biomedcentral.com/1471-2164/9/403 en_US
dc.identifier.uri http://hdl.handle.net/2271/620
dc.description.abstract BACKGROUND:The occurrence of liver cancer is higher in males than in females, and the incidence increases during aging. Signaling pathways regulated by retinoid × receptor a (RXRa) are involved in hepatocellular carcinogenesis. The phenotype of hepatocyte RXRa deficient mice is different between genders. To explore the impact of hepatocyte RXRa deficiency on gender-dependent hepatic gene expression, we compared the expression profiles of cancer-related genes in 6 and 24 month old male and female mice.RESULTS:In 6 month old mice, male mutant mice showed more cancer-related genes with alteration in mRNA levels than females did (195 vs. 60). In aged mice (24 month), female mutant mice showed greater deviation in mRNA expression levels of cancer-related genes than their male counterparts (149 vs. 82). The genes were classified into five categories according to their role in carcinogenesis: apoptosis, metastasis, cell growth, stress, and immune respnse. In each category, dependent upon age and gender, the genes as well as the number of genes with altered mRNA levels due to RXRa deficiency varies.CONCLUSION:The change in hepatic cancer-related gene expression profiles due to RXRa deficiency was gender- and age-dependent. The alteration of mRNA levels of cancer-related genes implied that aberrant RXRa signaling could potentially increase the risk of liver cancer and that retinoid signaling might contribute to gender- and age-associated liver cancer incidence. en_US
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dc.format.mimetype application/pdf
dc.format.mimetype text/plain
dc.format.mimetype application/octet-stream
dc.format.mimetype application/octet-stream
dc.format.mimetype application/octet-stream
dc.language en en_US
dc.language.iso en_US
dc.publisher BioMedCentral en_US
dc.relation.ispartof 1471-2164 en_US
dc.relation.hasversion http://www.biomedcentral.com/content/pdf/1471-2164-9-403.pdf en_US
dc.rights This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. en_US
dc.rights.uri http://creativecommons.org/licenses/by/2.0 en_US
dc.subject.mesh Bacterial Proteins/genetics en_US
dc.subject.mesh Base Sequence en_US
dc.subject.mesh DNA Transposable Elements/genetics en_US
dc.subject.mesh Evolution, Molecular en_US
dc.subject.mesh Gene Duplication en_US
dc.subject.mesh Gene Rearrangement en_US
dc.subject.mesh Gene Transfer, Horizontal en_US
dc.subject.mesh Genome, Bacterial/ genetics en_US
dc.subject.mesh Genomics en_US
dc.subject.mesh Microsatellite Repeats en_US
dc.subject.mesh Oryza sativa/ microbiology en_US
dc.subject.mesh Reproducibility of Results en_US
dc.subject.mesh Time Factors en_US
dc.subject.mesh Xanthomonas/ genetics en_US
dc.title Hepatocyte RXRalpha deficiency in matured and aged mice: impact on the expression of cancer-related hepatic genes in a gender-specific manner en_US
dc.type article en_US
dc.date.captured 2009-04-27 en_US
dc.identifier.doi doi:10.1186/1471-2164-9-403 en_US
dc.identifier.pmid 18452608 en_US

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This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Except where otherwise noted, this item's license is described as This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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