Gastroparesis secondary to a demyelinating disease: a case series

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dc.contributor.author Savio Reddymasu en_US
dc.contributor.author John Bonino en_US
dc.contributor.author Richard McCallum en_US
dc.date.accessioned 2009-05-05T16:44:00Z
dc.date.available 2007 - en_US
dc.date.available 2009-05-05T16:44:00Z
dc.date.issued 2006-05-15 en_US
dc.identifier.citation Savio Reddymasu;John Bonino;Richard McCallum: Gastroparesis secondary to a demyelinating disease: a case series. BMC Gastroenterol 2007, 7(1):3. en_US
dc.identifier.uri http://www.biomedcentral.com/1471-230X/7/3 en_US
dc.identifier.uri http://hdl.handle.net/2271/633
dc.description.abstract BACKGROUND:Gastroparesis has a number of etiologies. The main ones are secondary to a complication from diabetes mellitus, related to post vagotomy or post gastric surgical resections, or idiopathic when the etiology is unclear. Gastroparesis secondary to a demyelinating disease of the brain is unusual.CASE PRESENTATION:A 22-year-old woman was referred for acute onset of intractable nausea and vomiting. She also had cerebellar deficits, dysphagia and paresthesias. Magnetic resonance imaging (MRI) of the brain revealed an isolated area of demyelination in the medullary region. Another 24-year-old woman had a similar presentation with right hemiplegia and MRI of the brain revealed a distal medullary region. Both these patients had an abnormal gastric emptying test. Gastroparesis and neurological deficits improved with intravenous corticosteroids. While the former patient has had no further recurrences, the latter patient developed multiple sclerosis within three months of presentation.CONCLUSION:A demyelinating disease is a rare cause gastropareis, but should be suspected when symptoms of gastroparesis are associated with neurological deficits. MRI might help in the diagnosis and intravenous coriticosteroids can address the underlying disease process and improve gastric emptying, especially when used early during the course of the disease. en_US
dc.format.extent 404874 bytes
dc.format.extent 2910 bytes
dc.format.extent 12055 bytes
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dc.format.mimetype application/pdf
dc.format.mimetype text/plain
dc.format.mimetype application/octet-stream
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dc.format.mimetype application/octet-stream
dc.language en en_US
dc.language.iso en_US
dc.publisher BioMedCentral en_US
dc.relation.ispartof 1471-230X en_US
dc.relation.hasversion http://www.biomedcentral.com/content/pdf/1471-230X-7-3.pdf en_US
dc.rights This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. en_US
dc.rights.uri http://creativecommons.org/licenses/by/2.0 en_US
dc.subject.mesh Animals en_US
dc.subject.mesh Caerulein en_US
dc.subject.mesh Disease Models, Animal en_US
dc.subject.mesh Female en_US
dc.subject.mesh Gene Expression Regulation en_US
dc.subject.mesh Male en_US
dc.subject.mesh Mice en_US
dc.subject.mesh Mice, Inbred CFTR en_US
dc.subject.mesh Pancreas/metabolism en_US
dc.subject.mesh Pancreatitis/chemically induced/immunology/ metabolism en_US
dc.subject.mesh Peroxidase/metabolism en_US
dc.subject.mesh Proteins/ genetics/metabolism en_US
dc.subject.mesh RNA/metabolism en_US
dc.subject.mesh Regeneration en_US
dc.title Gastroparesis secondary to a demyelinating disease: a case series en_US
dc.type article en_US
dc.date.captured 2009-04-27 en_US
dc.identifier.doi doi:10.1186/1471-230X-7-3 en_US
dc.identifier.pmid 16700916 en_US

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This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Except where otherwise noted, this item's license is described as This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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