Imaging corticospinal tract connectivity in injured rat spinal cord using manganese-enhanced MRI

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dc.contributor.author Mehmet Bilgen en_US
dc.date.accessioned 2009-05-05T16:44:06Z
dc.date.available 2006 - en_US
dc.date.available 2009-05-05T16:44:06Z
dc.date.issued 2006-04-11 en_US
dc.identifier.citation Mehmet Bilgen: Imaging corticospinal tract connectivity in injured rat spinal cord using manganese-enhanced MRI. BMC Med Imaging 2006, 6(1):15. en_US
dc.identifier.uri http://www.biomedcentral.com/1471-2342/6/15 en_US
dc.identifier.uri http://hdl.handle.net/2271/634
dc.description.abstract BACKGROUND:Manganese-enhanced MRI (MEI) offers a novel neuroimaging modality to trace corticospinal tract (CST) in live animals. This paper expands this capability further and tests the utility of MEI to image axonal fiber connectivity in CST of injured spinal cord (SC).METHODS:A rat was injured at the thoracic T4 level of the SC. The CST was labeled with manganese (Mn) injected intracortically at two weeks post injury. Next day, the injured SC was imaged using MEI and diffusion tensor imaging (DTI) modalities.RESULTS:In vivo MEI data obtained from cervical SC confirmed that CST was successfully labeled with Mn. Ex vivo MEI data obtained from excised SC depicted Mn labeling of the CST in SC sections caudal to the lesion, which meant that Mn was transported through the injury, possibly mediated by viable CST fibers present at the injury site. Examining the ex vivo data from the injury epicenter closely revealed a thin strip of signal enhancement located ventrally between the dorsal horns. This enhancement was presumably associated with the Mn accumulation in these intact fibers projecting caudally as part of the CST. Additional measurements with DTI supported this view.CONCLUSION:Combining these preliminary results collectively demonstrated the feasibility of imaging fiber connectivity in experimentally injured SC using MEI. This approach may play important role in future investigations aimed at understanding the neuroplasticity in experimental SCI research. en_US
dc.format.extent 1249350 bytes
dc.format.extent 2910 bytes
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dc.format.mimetype application/pdf
dc.format.mimetype text/plain
dc.format.mimetype application/octet-stream
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dc.language en en_US
dc.language.iso en_US
dc.publisher BioMedCentral en_US
dc.relation.ispartof 1471-2342 en_US
dc.relation.hasversion http://www.biomedcentral.com/content/pdf/1471-2342-6-15.pdf en_US
dc.rights This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. en_US
dc.rights.uri http://creativecommons.org/licenses/by/2.0 en_US
dc.subject.mesh Bacterial Adhesion en_US
dc.subject.mesh Cell Line en_US
dc.subject.mesh Humans en_US
dc.subject.mesh Inflammation/ immunology en_US
dc.subject.mesh Interleukin-8/ metabolism en_US
dc.subject.mesh NF-kappa B/ metabolism en_US
dc.subject.mesh Pneumonia, Pneumococcal/microbiology en_US
dc.subject.mesh Pulmonary Alveoli/cytology/immunology/ microbiology en_US
dc.subject.mesh Streptococcus pneumoniae/classification/ physiology en_US
dc.title Imaging corticospinal tract connectivity in injured rat spinal cord using manganese-enhanced MRI en_US
dc.type article en_US
dc.date.captured 2009-04-27 en_US
dc.identifier.doi doi:10.1186/1471-2342-6-15 en_US
dc.identifier.pmid 16606470 en_US

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This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Except where otherwise noted, this item's license is described as This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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