Cardiac dysfunction in the diabetic rat: quantitative evaluation using high resolution magnetic resonance imaging

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dc.contributor.author Rajprasad Loganathan en_US
dc.contributor.author Mehmet Bilgen en_US
dc.contributor.author Baraa Al-Hafez en_US
dc.contributor.author Mohammed Alenezy en_US
dc.contributor.author Irina Smirnova en_US
dc.date.accessioned 2009-05-05T19:39:55Z
dc.date.available 2006 - en_US
dc.date.available 2009-05-05T19:39:55Z
dc.date.issued 2004-08-10 en_US
dc.identifier.citation Rajprasad Loganathan;Mehmet Bilgen;Baraa Al-Hafez;Mohammed Alenezy;Irina Smirnova: Cardiac dysfunction in the diabetic rat: quantitative evaluation using high resolution magnetic resonance imaging. Cardiovasc Diabetol 2006, 5(1):7. en_US
dc.identifier.uri http://www.cardiab.com/content/5/1/7 en_US
dc.identifier.uri http://hdl.handle.net/2271/635
dc.description.abstract BACKGROUND:Diabetes is a major risk factor for cardiovascular disease. In particular, type 1 diabetes compromises the cardiac function of individuals at a relatively early age due to the protracted course of abnormal glucose homeostasis. The functional abnormalities of diabetic myocardium have been attributed to the pathological changes of diabetic cardiomyopathy.METHODS:In this study, we used high field magnetic resonance imaging (MRI) to evaluate the left ventricular functional characteristics of streptozotocin treated diabetic Sprague-Dawley rats (8 weeks disease duration) in comparison with age/sex matched controls.RESULTS:Our analyses of EKG gated cardiac MRI scans of the left ventricle showed a 28% decrease in the end-diastolic volume and 10% increase in the end-systolic volume of diabetic hearts compared to controls. Mean stroke volume and ejection fraction in diabetic rats were decreased (48% and 28%, respectively) compared to controls. Further, dV/dt changes were suggestive of phase sensitive differences in left ventricular kinetics across the cardiac cycle between diabetic and control rats.CONCLUSION:Thus, the MRI analyses of diabetic left ventricle suggest impairment of diastolic and systolic hemodynamics in this rat model of diabetic cardiomyopathy. Our studies also show that in vivo MRI could be used in the evaluation of cardiac dysfunction in this rat model of type 1 diabetes. en_US
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dc.language en en_US
dc.language.iso en_US
dc.publisher BioMedCentral en_US
dc.relation.ispartof 1475-2840 en_US
dc.relation.hasversion http://www.biomedcentral.com/content/pdf/1475-2840-5-7.pdf en_US
dc.rights This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. en_US
dc.rights.uri http://creativecommons.org/licenses/by/2.0 en_US
dc.subject.mesh African Americans/ statistics & numerical data en_US
dc.subject.mesh Aged en_US
dc.subject.mesh Aged, 80 and over en_US
dc.subject.mesh Anti-Bacterial Agents/therapeutic use en_US
dc.subject.mesh Community-Acquired Infections/diagnosis/ethnology/mortality/ therapy en_US
dc.subject.mesh European Continental Ancestry Group/ statistics & numerical data en_US
dc.subject.mesh Female en_US
dc.subject.mesh Guideline Adherence en_US
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dc.subject.mesh United States en_US
dc.title Cardiac dysfunction in the diabetic rat: quantitative evaluation using high resolution magnetic resonance imaging en_US
dc.type article en_US
dc.date.captured 2009-04-27 en_US
dc.identifier.doi doi:10.1186/1475-2840-5-7 en_US
dc.identifier.pmid 15304197 en_US

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This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Except where otherwise noted, this item's license is described as This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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