A model-based time-reversal of left ventricular motion improves cardiac motion analysis using tagged MRI data

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dc.contributor.author Tareq Alrefae en_US
dc.contributor.author Irina Smirnova en_US
dc.contributor.author Larry Cook en_US
dc.contributor.author Mehmet Bilgen en_US
dc.date.accessioned 2009-05-05T19:40:02Z
dc.date.available 2008 - en_US
dc.date.available 2009-05-05T19:40:02Z
dc.date.issued 2006-01-09 en_US
dc.identifier.citation Tareq Alrefae;Irina Smirnova;Larry Cook;Mehmet Bilgen: A model-based time-reversal of left ventricular motion improves cardiac motion analysis using tagged MRI data. Biomed Eng Online 2008, 7(1):15. en_US
dc.identifier.uri http://www.biomedical-engineering-online.com/content/7/1/15 en_US
dc.identifier.uri http://hdl.handle.net/2271/636
dc.description.abstract BACKGROUND:Myocardial motion is an important observable for the assessment of heart condition. Accurate estimates of ventricular (LV) wall motion are required for quantifying myocardial deformation and assessing local tissue function and viability. Harmonic Phase (HARP) analysis was developed for measuring regional LV motion using tagged magnetic resonance imaging (tMRI) data. With current computer-aided postprocessing tools including HARP analysis, large motions experienced by myocardial tissue are, however, often intractable to measure. This paper addresses this issue and provides a solution to make such measurements possible.METHODS:To improve the estimation performance of large cardiac motions while analyzing tMRI data sets, we propose a two-step solution. The first step involves constructing a model to describe average systolic motion of the LV wall within a subject group. The second step involves time-reversal of the model applied as a spatial coordinate transformation to digitally relax the contracted LV wall in the experimental data of a single subject to the beginning of systole. Cardiac tMRI scans were performed on four healthy rats and used for developing the forward LV model. Algorithms were implemented for preprocessing the tMRI data, optimizing the model parameters and performing the HARP analysis. Slices from the midventricular level were then analyzed for all systolic phases.RESULTS:The time-reversal operation derived from the LV model accounted for the bulk portion of the myocardial motion, which was the average motion experienced within the overall subject population. In analyzing the individual tMRI data sets, removing this average with the time-reversal operation left small magnitude residual motion unique to the case. This remaining residual portion of the motion was estimated robustly using the HARP analysis.CONCLUSION:Utilizing a combination of the forward LV model and its time reversal improves the performance of motion estimation in evaluating the cardiac function. en_US
dc.format.extent 1462533 bytes
dc.format.extent 2910 bytes
dc.format.extent 12055 bytes
dc.format.extent 14320 bytes
dc.format.extent 43 bytes
dc.format.mimetype application/pdf
dc.format.mimetype text/plain
dc.format.mimetype application/octet-stream
dc.format.mimetype application/octet-stream
dc.format.mimetype application/octet-stream
dc.language en en_US
dc.language.iso en_US
dc.publisher BioMedCentral en_US
dc.relation.ispartof 1475-925X en_US
dc.relation.hasversion http://www.biomedcentral.com/content/pdf/1475-925X-7-15.pdf en_US
dc.rights This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. en_US
dc.rights.uri http://creativecommons.org/licenses/by/2.0 en_US
dc.subject.mesh Algorithms en_US
dc.subject.mesh Animals en_US
dc.subject.mesh Equipment Design en_US
dc.subject.mesh Implants, Experimental en_US
dc.subject.mesh Magnetic Resonance Imaging/ instrumentation en_US
dc.subject.mesh Rats en_US
dc.subject.mesh Rats, Sprague-Dawley en_US
dc.subject.mesh Spinal Cord/anatomy & histology en_US
dc.subject.mesh Subcutaneous Tissue en_US
dc.title A model-based time-reversal of left ventricular motion improves cardiac motion analysis using tagged MRI data en_US
dc.type article en_US
dc.date.captured 2009-04-27 en_US
dc.identifier.doi doi:10.1186/1475-925X-7-15 en_US
dc.identifier.pmid 16401343 en_US

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This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Except where otherwise noted, this item's license is described as This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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