Oleanolic acid (OA) is a triterpenoid compound, which is a natural ingredient in some Chinese herbal medicines used for the treatment of hepatitis. OA has previously been shown in our laboratory to diminish the hepatotoxicity ...

Autosomal dominant polycystic kidney disease (ADPKD) is characterized by multiple fluid-filled cysts resulting from increased proliferation and alterations in the fluid transport properties of the renal epithelium. The ...

Introduction. Alpha activity during wakefulness is thought to represent perceptual disengagement and a state of relaxation. Patients with primary insomnia (PIs) have often been observed exhibiting less alpha activity ...

High throughput gene expression analysis before and after the LH surge has provided insight into the diversity of ovarian genes involved in oocyte maturation, ovulation, and luteinization. However, steady state gene ...

Breast and ovarian cancer are leading causes of cancer-related deaths among women, responsible for over 56,000 fatalities annually in the United States. Women at increased risk for breast cancer are often also at increased ...

Background: It has been shown that people with lesions of the basal ganglia including Parkinson’s disease (PD) have impaired procedural learning, but the functional significance of this deficit is uncertain. Purpose: The ...

ZIP4 and ZIP5 belong to the Zrt-Irt-like proteins (SLC39A) family of metal ion transporters. Mutations in hZIP4 cause acrodermatitis enteropathica, which reflects an inability to absorb adequate zinc. ZIP5 is a close ...

Trophoblast cells are essential for the establishment and maintenance of pregnancy. In rodents, trophoblast giant cells are located at the maternal-embryonic interface and represent one of the major endocrine cell types ...

Retinoids refer to natural and synthetic derivatives of vitamin A, which play multiple roles in embryogenesis, development, vision, homeostasis as well as proliferation and apoptosis. In the current study, a panel of 13 ...

There are sex differences in the sensory experience of pain. For example, the incidence of chronic pain syndromes is higher in women than in men. Studies of gonadal steroid modulation of pain have, to date, focused on ...