The role of Hoxb1 in patterning calvarial bone during development

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Show simple item record Chennault, Rachel 2006-05-22T16:37:45Z 2006-05-22T16:37:45Z 2006-05-22T16:37:45Z
dc.description Molecular and Cell Biology I Room G027 Dykes 9:32 AM Abstract 220 en
dc.description.abstract Cranial sutures represent growth centers that permit calvarial bone growth during embryonic and postnatal life. This bone growth is accomplished through a series of tissue interactions involving the brain, suture mesenchyme, osteogenic fronts, and underlying dura mater. In order for the sutures to allow further bone growth, they must remain patent (non-fusing), so that bone may be formed at the edges of the developing osteogenic fronts. Two common human congenital deformities result from abnormal suture formation and maintenance. The first, Craniosynostosis, occurs when sutures fuse prematurely during development, resulting in a severely malformed skull. This disorder has been linked to mutations in several genes important during development, such as FGFR1-3, MSX2, and TWIST. Cleidocranial Dysplasia (CCD) results from failure to close the sagittal suture, and the anterior and posterior fontanelles remain patent. Previous studies have shown that the variable severity of phenotypes arises from key mutations in the DNA-binding regions of RUNX2, a gene known to be critical to bone formation. In our lab, a mouse cranial suture phenotype has been identified in Hoxb1 adults and embryonic mutants.The edges of the opposing parietal bones at the site of the sagittal suture appear rounded in mutant embryos, similar to the human and mouse CCD phenotypes (Mundlos et al, 1997; Otto et al, 1997). In addition, we have noted in adult Hoxb1+/- mice that the lambdoid and coronal sutures fail to form properly. For these reasons, I propose that Hoxb1 plays an important role in patterning calvarial bone during development. en
dc.description.sponsorship Krumlauf, Robb Anatomy and Cell Biology en
dc.format.extent 45765120 bytes
dc.format.mimetype application/
dc.language.iso en_US en
dc.title The role of Hoxb1 in patterning calvarial bone during development en
dc.type Presentation en

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