Comparison of a reduced carbohydrate and reduced fat diet for LDL, HDL, and VLDL subclasses during 9-months of weight maintenance subsequent to weight loss

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dc.contributor.author LeCheminant, James D
dc.contributor.author Smith, Bryan K
dc.contributor.author Westman, Eric C
dc.contributor.author Vernon, Mary C
dc.contributor.author Donnelly, Joseph E
dc.date.accessioned 2010-10-12T16:28:54Z
dc.date.available 2010-10-12T16:28:54Z
dc.date.issued 2010-06-01
dc.identifier http://dx.doi.org/10.1186/1476-511X-9-54
dc.identifier.uri http://hdl.handle.net/2271/875
dc.description.abstract Abstract Objectives This study compared LDL, HDL, and VLDL subclasses in overweight or obese adults consuming either a reduced carbohydrate (RC) or reduced fat (RF) weight maintenance diet for 9 months following significant weight loss. Methods Thirty-five (21 RC; 14 RF) overweight or obese middle-aged adults completed a 1-year weight management clinic. Participants met weekly for the first six months and bi-weekly thereafter. Meetings included instruction for diet, physical activity, and behavior change related to weight management. Additionally, participants followed a liquid very low-energy diet of ~2092 kJ per day for the first three months of the study. Subsequently, participants followed a dietary plan for nine months that targeted a reduced percentage of carbohydrate (~20%) or fat (~30%) intake and an energy intake level calculated to maintain weight loss. Lipid subclasses using NMR spectroscopy were analyzed prior to weight loss and at multiple intervals during weight maintenance. Results Body weight change was not significantly different within or between groups during weight maintenance (p > 0.05). The RC group showed significant increases in mean LDL size, large LDL, total HDL, large and small HDL, mean VLDL size, and large VLDL during weight maintenance while the RF group showed increases in total HDL, large and small HDL, total VLDL, and large, medium, and small VLDL (p < 0.05). Group*time interactions were significant for large and medium VLDL (p > 0.05). Conclusion Some individual lipid subclasses improved in both dietary groups. Large and medium VLDL subclasses increased to a greater extent across weight maintenance in the RF group.
dc.title Comparison of a reduced carbohydrate and reduced fat diet for LDL, HDL, and VLDL subclasses during 9-months of weight maintenance subsequent to weight loss
dc.type Journal Article
dc.date.updated 2010-06-23T00:07:17Z
dc.description.version Peer Reviewed
dc.language.rfc3066 en
dc.rights.holder LeCheminant et al.; licensee BioMed Central Ltd.

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