Assessment of large fiber proprioceptive deficits and spindle innervation in diabetic mice

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Show simple item record Jones, Karra 2006-05-23T14:25:39Z 2006-05-23T14:25:39Z 2006-05-23T14:25:39Z
dc.description Neuroscience I Room 1028 Dykes 9:08 AM Abstract 197 en
dc.description.abstract Diabetic neuropathy (DN) is a common complication of both diabetes mellitus type I and II. DN has traditionally been described as a “dying-back” neuropathy, where the distal ends of sensory axons degenerate and denervate peripheral tissues. Patients with DN can show a loss of large- and/or small-diameter sensory fibers. When large fibers are involved, the patients exhibit proprioceptive deficits and impaired balance. Muscle spindles are innervated by both sensory and motor neurons and send proprioceptive information about the muscle to the central nervous system. To date, no studies have specifically addressed the innervation of muscle spindles in the setting of DN. We hypothesize that diabetes-induced denervation of muscle spindles underlies, in part, the development of proprioceptive abnormalities in DN. To test this hypothesis, we utilize a mouse model of type I diabetes induced by streptozotocin. To explore the relationship between muscle spindle deficits and proprioception, we are evaluating the proprioceptive abilities of control and diabetic mice using a rotorod, which tests coordination and balance. In addition, muscle spindle innervation is evaluated in the gastrocnemius muscle using immunohistochemical techniques. Using antibodies against S46 to visualize spindle bag fibers and neurofilament heavy chain to visualize sensory and motor axons innervating the spindles, and bungarotoxin to label the neuromuscular junction, the sensory (Ia and II) and motor (gamma) innervation of the spindle is assessed. Overall, these results will provide important information about the relationship between muscle spindles and proprioceptive deficits in DN. en
dc.description.sponsorship Wright, Douglas, Anatomy and Cell Biology en
dc.format.extent 1111040 bytes
dc.format.mimetype application/
dc.language.iso en_US en
dc.subject Diabetic neuropathy en
dc.subject Proprioception en
dc.subject Muscle spindle en
dc.title Assessment of large fiber proprioceptive deficits and spindle innervation in diabetic mice en
dc.type Presentation en

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