Prostate Cancer is one of the most common malignancies in the US. Activation of androgen receptor (AR) has been shown to play a critical role in the initiation, maintenance and progression of prostate cancer. In an attempt ...
Traumatic Brain Injury (TBI) annually affects 1.5 million individuals in the United States and associated costs soar to over $56 billion. Despite its widespread burden, relatively little is known about how to reduce the ...
Background: High-risk human papilloma virus (HR-HPV) is a recognized cause of cervical carcinoma and its precursors. HPV
testing is recommended to triage the follow up for women with atypical squamous cells of undetermined ...
Currently, hydroxyurea (HU), a potent inducer of fetal hemoglobin (Hb F), is the only approved drug for the management of sickle cell disease (SCD).Although the mechanism of induction of Hb F by HU is still unknown, but ...
Human T-cell lymphoma/leukemia virus (HTLV) is the etiological agent of adult T-cell lymphoma (ATL). Over10-20 million
people are infected with HTLV, which is endemic in regions of Japan, the Caribbean, South America, ...
Certified nursing assistants (CNAs) are frontline caregivers for the elderly with chronic physical and cognitive disabilities in nursing homes (NHs). The pool of CNAs available to deliver this complex care in NHs is ...
The vertebrate body plan is characterized by a segmented organization, which is clearly visible at the level of the vertebral column, its associated muscles and the peripheral nervous system. This basic organization is ...
Background: Alzheimer’s disease (AD) is the most common cause of memory loss in the world today. Non-invasive neuroimaging techniques have been explored to help diagnose and perhaps predict AD before the onset of symptoms. ...
The hypothesis of this project was that extended exposure to microgravity has a negative impact on the ability of the male
mammalian species to reproduce. Previous research showed that simulated microgravity using hindlimb ...
Fragile X syndrome (FXS) is caused by an expanded trinucleotide repeat in the fragile X mental retardation gene (FMR1). Premutation alleles (55-200 CGG repeats) of FMR1 are known to contribute to the fragile X phenotype ...
Nerve injury resulting from trauma frequently leads to loss of function due to neuronal degeneration and cell death. The
molecular mechanisms involved in neuronal cell death are poorly understood, but are thought to ...
Each year there are tens of millions of unplanned pregnancies and subsequent abortions worldwide. The WHO, NIH and IOM
have identified the need for the development of an effective reversible male contraceptive agent. ...
Oleanolic acid (OA) is a triterpenoid compound, which is a natural ingredient in some Chinese herbal medicines used for the treatment of hepatitis. OA has previously been shown in our laboratory to diminish the hepatotoxicity ...
Docosohexaenoic acid (DHA; 226n-3) is an omega-3 fatty acid critical for normal brain function. DHA in humans is
incorporated late in gestation and postnatally, during periods of rapid brain development. We hypothesized ...
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by multiple fluid-filled cysts resulting from
increased proliferation and alterations in the fluid transport properties of the renal epithelium. The ...
As nursing homes become a dominant setting for death in the United States, palliative care must be integrated into daily nursing home practices. Improvements in this area will be better evaluated if researchers can assess ...
Introduction.
Alpha activity during wakefulness is thought to represent perceptual disengagement and a state of relaxation. Patients with primary insomnia (PIs) have often been observed exhibiting less alpha activity ...
Purpose: To compare handwriting legibility among professions. Methods: A convenience sample, stratified by gender, of 20 right-handed volunteers each from 7 occupations, rapidly wrote the sentence “The quick brown fox ...
High throughput gene expression analysis before and after the LH surge has provided insight into the diversity of ovarian
genes involved in oocyte maturation, ovulation, and luteinization. However, steady state gene ...
Quinpirole sensitization is used as an animal model of obsessive-compulsive disorder (OCD), a psychiatric disorder characterized by excessive, repetition of an obsession and/or compulsion. Clorgyline, an MAOA inhibitor, ...